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Also, nothing to do with your issue but you don't seem to be doing compression. Steve, I'll have to verify the authentication we are using with activesync.
Outlook Anywhere NTLM authentication has always been a bit of a tricky beast when using a pre-authenticating reverse proxy like TMG or UAG.
Because every environment is different (for example your settings may be configured differently), you may need to consult your Microsoft Forefront TMG documentation.
For more advanced configuration, you should consult the Microsoft documentation.
In your case things may be a bit more 'nuanced' but I'd certainly disable it all round and see if this solves the first issue. Compression is definitely a good idea for any HTTP traffic and will reduce bandwidth usage and improve apparent client performance significantly.
I'd recommend it, but implement it only on one set of F5's.Searched the registry for “ms FPCIntra Array Address” and changed the ip on them (I think I could find it in 4 places in the registry). Rebooted the server and following alert did not show anymore: The IP address specified for communication between this Forefront TMG computer (194.1) and other array members is not bound to a network adapter installed on this computer.