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Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
Care should be taken to avoid extravasation of Levophed into the tissues, as local necrosis might ensue due to the vasoconstrictive action of the drug.
Therefore, one should avoid the veins of the leg in elderly patients or in those suffering from such disorders.
Gangrene has been reported in a lower extremity when infusions of Levophed were given in an ankle vein.
Levophed functions as a peripheral vasoconstrictor (alpha-adrenergic action) and as an inotropic stimulator of the heart and dilator of coronary arteries (beta-adrenergic action).
For blood pressure control in certain acute hypotensive states (e.g., pheochromocytomectomy, sympathectomy, poliomyelitis, spinal anesthesia, myocardial infarction, septicemia, blood transfusion, and drug reactions).Levophed infusions should not be administered into the veins in the leg in elderly patients (see PRECAUTIONS, General) .